Reference protocol
🩺 Auto-injector · Epinephrine
ANAPHYLAXIS — FLOWCHART
Version May 20, 2022
ANAPHYLACTIC-TYPE ALLERGIC REACTIONS
Has there been contact with a known or suspected allergen
in the last 12 hours?
Reassess frequently
the signs and symptoms
⏱ every 5 minutes
the signs and symptoms
⏱ every 5 minutes
NO
YESMAYBE
Is there a sudden and rapid onset of at least 1 symptom in 2 of these 4 categories?
— OR — a severe reaction in only one category?
🫃 Digestive
Vomiting
Diarrhea
Abdominal cramps
🫁 Respiratory
Shortness of breath
Cough
Wheezing
Airway swelling
Runny nose
Hoarse voice
🫦 Mouth / Skin
Itching
Red patches
Swelling
🩸 Blood pressure
Dizziness
Fainting
Drowsiness
Severe weakness
YES
💉 Administer
the auto-injector
📞 Call 911
Note the time of administration
Note the time of administration
Reassess signs and symptoms
⏱ every 5 minutes
⏱ every 5 minutes
If still present without improvement
2nd dose of epinephrine
⏱ after 5 minutesAdditional doses possible every 15 min
🏥 Seek care at a hospital
by calling 911
by calling 911
Are you in doubt?
YES
💉 Administer
the auto-injector
📞 Call 911
Note the time
Note the time
Reassess every
⏱ 5 minutes
⏱ 5 minutes
🏥 Hospital
via 911
NO
DO NOT administer
the auto-injector
Reassess signs
and symptoms
⏱ every 5 min
and symptoms
⏱ every 5 min
NO
DO NOT administer
the auto-injector
Reassess frequently
the signs and symptoms
⏱ every 5 minutes
the signs and symptoms
⏱ every 5 minutes
To watch for
If symptoms evolve and an anaphylactic reaction is confirmed, reassess the decision to administer.